Creatinine, calcium, CTX/TRAP index, BGP, and PINP serum levels in female Wistar rats at the end of the study. Six-month-old rats at the beginning of the study were ovariectomized (OVX) or sham-operated (SHAM) and randomized in the following groups: SHAM group (SHAM) treated with vehicle for 3 months; ovariectomized group (OVX) treated also with vehicle for 3 months; ovariectomized group treated with Kalsis at a dose of 25 mg/kg/day, for 3 months (OVX + K25). Statistical significance P < 0.05: a versus SHAM.