Table 2.
Bone Area (BA), bone mineral content (BMC), and bone mineral density (BMD) measured in femur and in lumbar vertebra in female Wistar rats at the end of the study. Six-month-old rats at the beginning of the study, ovariectomized (OVX) or sham-operated (SHAM) were randomized in the following groups: SHAM group (SHAM), treated with vehicle for 3 months; ovariectomized group (OVX) also treated with vehicle for 3 months; ovariectomized group treated with Kalsis at a dose of 25 mg/kg/day, for 3 months (OVX + K25). Statistical significance P < 0.05: a versus SHAM; b versus OVX.
| BA (cm2) | BMC (g) | BMD (cm2/g) | |
|---|---|---|---|
| Femoral | |||
|
| |||
| SHAM |
1.730 ± 0.15 | 0.485 ± 0.072 |
0.280 ± 0.017 |
| OVX |
1.869 ± 0.069a | 0.474 ± 0.074 | 0.263 ± 0.011a |
| OVX + K25 | 1.847 ± 0.122a | 0.506 ± 0.05 | 0.273 ± 0.011b |
|
| |||
| Lumbar | |||
|
| |||
| SHAM | 1.423 ± 0.127 | 0.326 ± 0.054 | 0.235 ± 0.021 |
| OVX | 1.499 ± 0.104 | 0.324 ± 0.038 | 0.216 ± 0.013a |
| OVX + K25 | 1.526 ± 0.123a | 0.347 ± 0.053 | 0.227 ± 0.017b |