Table 2.
Liver function test. Male and female rats received vehicle (CMC), 100 mg/kg or 1000 mg/kg dentatin for 14 days. Liver function was examined by measuring total protein, albumin, globulin, or enzymes (TB, CB, AP, ALT, AST, and GGT) level in serum.
| Dose | Total protein (g/L) | Albumin (g/L) | Globulin (g/L) | TB (μmol/L) | CB (μmol/L) | AP (IU/L) | ALT (IU/L) | AST (IU/L) | GGT (IU/L) |
|---|---|---|---|---|---|---|---|---|---|
| Male rats (n = 6) | |||||||||
|
| |||||||||
| Vehicle (CMC) | 61.13 ± 3.13 | 9.16 ± 0.53 | 51.39 ± 1.93 | 2.13 ± 0.17 | 1.00 ± 0.00 | 154.07 ± 7.31 | 50.81 ± 3.71 | 173.53 ± 7.17 | 3.17 ± 0.16 |
| Dentatin 100 mg/kg | 59.97 ± 2.18 | 8.67 ± 0.33 | 49.73 ± 3.69 | 2.11 ± 0.15 | 1.00 ± 0.00 | 156.33 ± 6.24 | 48.02 ± 2.33 | 178.18 ± 6.84 | 3.37 ± 0.42 |
| Dentatin 1000 mg/kg | 62.04 ± 3.29 | 9.70 ± 0.47 | 50.08 ± 2.75 | 2.08 ± 0.10 | 1.00 ± 0.00 | 155.17 ± 5.09 | 46.52 ± 2.16 | 175.87 ± 7.15 | 3.17 ± 0.15 |
|
| |||||||||
| Female rats (n = 6) | |||||||||
|
| |||||||||
| Vehicle (CMC) | 64.48 ± 2.47 | 11.27 ± 0.41 | 53.37 ± 3.34 | 2.00 ± 0.00 | 1.00 ± 0.00 | 104.81 ± 6.33 | 43.05 ± 2.96 | 171.39 ± 5.86 | 3.77 ± 0.33 |
| Dentatin 100 mg/kg | 65.21 ± 3.58 | 12.00 ± 0.57 | 54.68 ± 3.59 | 2.00 ± 0.00 | 1.00 ± 0.00 | 101.33 ± 4.98 | 41.87 ± 2.73 | 173.08 ± 6.65 | 3.52 ± 0.51 |
| Dentatin 1000 mg/kg | 65.33 ± 2.78 | 11.50 ± 0.45 | 54.08 ± 2.77 | 2.00 ± 0.00 | 1.00 ± 0.00 | 103.86 ± 5.86 | 44.15 ± 3.89 | 173.81 ± 5.81 | 3.05 ± 0.24 |
TB: Total bilirubin; CB: conjugated bilirubin; AP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: γ-glutamyltransferase.