Table 1.
Summary of gating parameters
| Kv1.4 | Kv1.4[P558G] | Kv1.4 ΔN | Kv1.4 [P558G]ΔN | |
|---|---|---|---|---|
| Activation | ||||
| Vhalf activation | −28.2 ± 2.5 mV∗ | 37.4 ± 1.4 mV∗ | −27.5 ± 1.6 mV† | 38.9 ± 1.3 mV† |
| Slope factor | 11.5 ± 1.0‡ | 14.2 ± 0.4‡ | 11.8 ± 1.0§ | 13.9 ± 0.2§ |
| Inactivation | ||||
| Vhalf inactivation | −51.8 ± 1.0 mV¶ | 2.3 ± 1.1 mV¶ | −45.5 ± 0.8 mV|| | 2.9 ± 2.1 mV|| |
| Slope factor | 3.2 ± 0.1∗∗ | 8.0 ± 0.5∗∗ | 3.6 ± 0.2†† | 11.3 ± 0.6†† |
| Recovery from inactivation | ||||
| τ | 4.5 ± 0.3 s | 5.0 ± 0.4 s | ||
Superscripts denote comparison between the same measurements of WT and N-terminal deletion constructs with their respective P558G mutant constructs (e.g., ∗compares Vhalf activation of Kv1.4 and Kv1.4[P558G]). All pairs were statistically significantly different (∗,†,‡,§.¶,||,∗∗,†† p ≪ 0.001). Data are mean ± SE.