Figure 2.
Coupling between the folding of individual repeats. The correlation between the degree of folding of all pairs of repeat units in various ANK (top) and TPR (bottom) systems. The correlation between each pair of repeats was calculated (it indicates the cooperativity in folding of this pair, where strong correlation implies that these two units tend to fold and unfold cooperatively). The ratio λ = (N × εinter)/(M × εintra) values are shown above the matrices. The matrices of the correlation between the folding of the repeats in unmodified ANK10 and TPR10 are shown on the left. The correlation coefficients between the pairs of repeats are based on the Q value of each repeat throughout the folding reactions of these proteins at TF.