Figure 5.

Probability of interfacial contacts occurring in ANK and TPR in the transition-state ensemble of a folding reaction. The probability of each contact occurring in the transition state (as measured by the fraction of frames by which this contact is formed in the transition-state ensemble) for (A) an unmodified ANK system and (B) the TPR system (three central units are shown; red: higher probability, blue: lower probability). In the ANK system, the interfacial contacts between the loops tend to form in a higher fraction than the interfacial contacts between the helices. In the TPR system, the contacts that are formed at the transition-state ensemble are more evenly distributed in the interface.