Figure 6.

Model simulations of matrix AdN content time course data from the experiments of Austin and Aprille (20). The matrix AdN time course is governed by Eq. 16 and includes the experimentally measured residual matrix AdN content (see text for detail). For simulating the matrix AdN content time course, matrix pH was set at 7.8 based on a ΔpH of 0.4, determined by Joyal and Aprille (5) under the same experimental conditions. In these experiments, isolated rat liver mitochondria were incubated with different external ATP and the net change in matrix AdN content was measured.