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A. Schematic diagram showing the NFκB heterodimer of p50 (green) and p65 (red) in complex with the ankyrin repeat domain of IκBα (gray). Both p50 and p65 consist of two immunoglobulin-like domains (shown as ellipses), an N-terminal DNA-binding domain and a C-terminal dimerization domain. B, C. Backbone ribbon showing the X-ray crystal structures of the NFκB(p65/p50)/IκBα complex. B. 1NFI (Jacobs and Harrison, 1998); C. 1IKN (Huxford et al., 1998).
