Figure 1.
A. Schematic diagram showing the NFκB heterodimer of p50 (green) and p65 (red) in complex with the ankyrin repeat domain of IκBα (gray). Both p50 and p65 consist of two immunoglobulin-like domains (shown as ellipses), an N-terminal DNA-binding domain and a C-terminal dimerization domain. B, C. Backbone ribbon showing the X-ray crystal structures of the NFκB(p65/p50)/IκBα complex. B. 1NFI (Jacobs and Harrison, 1998); C. 1IKN (Huxford et al., 1998).