Table 1.
Expression microarray analysis of the effects of IL-11 on the mouse fundic mucosa
| Symbol | 24 h IL-11 vs control | 7 day IL-11 vs control |
|---|---|---|
| Immune response | ||
| Serpina3n | 10.9 | 16.7 |
| Hp | * | 12.9 |
| Dmbt1 | 6.4 | 8.1† |
| Lcn2 | * | 7.1 |
| Ly6d | * | 5.8 |
| Serpina3g | 3.1 | 6.6 |
| Spp1 | 4.3 | 5.3 |
| C4a | * | 5.0 |
| Ifitm1 | 2.9 | 5.0 |
| Pigr | 2.5 | 4.3 |
| Serpina3m | * | 3.7 |
| Cxcl17 | * | 3.4 |
| Ifitm3 | 2.6 | 3.4 |
| Il33 | 2.4† | 3.4† |
| Cxcl13 | * | 3.2 |
| Osmr | 1.8 | 2.8 |
| Ly6a | * | 2.4 |
| Cf1 | * | 2.3 |
| Cxcl14 | * | 2.2 |
| Serpinb1a | 2.2 | 2.2 |
| Serpinf2 | * | 2.1 |
| Irf1 | 2.1 | * |
| Icam1 | * | 1.8 |
| Tnfrsf12a | * | 1.7 |
| Myd88 | 1.9 | 1.7 |
| Proliferation/apoptosis/differentiation | ||
| Reg3b | 64.3 | 146.7 |
| Reg1 | 24.7 | 63.2 |
| Reg3g | 13.4 | 39.9 |
| Wfdc2 | * | 6.0† |
| Reg3a | 1.5 | 5.5 |
| Igfbp4 | 2.1 | 3.7† |
| Bmp1 | * | 3.3 |
| Gadd45g | 2.6 | 2.5 |
| Gsdmc1 | 1.9 | 2.1 |
| Grem1 | 2.0 | 2.0 |
| Bcl3 | 1.6 | 1.9 |
| Muc1 | 1.9 | * |
| Sfrp1 | * | 1.8 |
| Reg3d | * | 1.8 |
| Klf5 | * | 1.7 |
| Mki67 | * | 1.6 |
| Shh | * | 1.5 |
| Gdf9 | * | −6.1 |
| Blm | −4.0 | −5.6 |
| Mist1 | * | −2.3 |
| Bmpr1b | * | −2.1 |
| Tob1 | * | −2.0 |
| Egf | * | −2.0 |
| Transport | ||
| Aqp5 | 2.1 | 5.2† |
| Kcnk1 | * † | 1.7† |
| Kcng4 | 1.7 | * |
| Slc38a5 | * | −3.9 |
| Slc26a9 | * † | −2.7† |
| Kcnj16 | * † | −2.6† |
| Kcnk5 | * | −2.5 |
| Kcnf1 | * † | −2.3† |
| Kcnj15 | * † | −2.0† |
| Aqp4 | −2.0 | * |
| Atp2c1 | * | −1.7 |
| Slc5a8 | * † | −1.7† |
| Slc16a5 | * | −1.6 |
| Slc25a12 | * | −1.6 |
| Slc26a6 | * † | −1.5† |
| Slc24a3 | 1.5† | * † |
| Protein degradation | ||
| Timp1 | 5.4† | 6.9† |
| Mmp3 | 1.8 | 2.1† |
| Adam28 | 1.9 | 2.0 |
| Adamdec1 | * | 1.8 |
| Efemp2 | 1.6 | 1.7 |
| Mmp23 | * | 1.7 |
| Mmp13 | * | 1.6 |
| Try10 | * | −33.1 |
| Try4 | * | −21.1 |
| Amy2 | * | −22.3 |
| Cpm | −1.9 | −2.3 |
| Endocrine | ||
| Chgb | * | 1.9 |
| Car11 | * | 1.5 |
| Gper | −2.8 | −5.2 |
| Sstr2 | * | −2.2 |
| Cckbr | −1.8† | −2.0† |
| Ddc | −1.6 | −1.8 |
| Signal transduction | ||
| Socs3 | 5.2 | 6.6 |
| Stat3 | * | 2.0 |
| Socs2 | * | 1.8 |
| Jak3 | 1.8 | 1.7 |
| Junb | 1.7 | 1.6 |
| Il-11ra1 | * | −1.6 |
Listed are transcripts of interest that had a fold changed 1.5 or greater and an adjusted p value of 0.05 or less for either 24 h or 7 days treatment with IL-11. Transcripts are clustered into six distinct functional groups; immune response, signal transduction, proliferation/apoptosis/differentiation, transport, protein degradation and endocrine.
*
Indicates expression at this time point not significantly altered by IL-11 expression.
†
Indicates transcriptional regulation confirmed by quantitative PCR analysis.