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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Nat Neurosci. 2012 Sep 2;15(10):1359–1361. doi: 10.1038/nn.3204

Fig. 1. CIE impairs fear extinction.

Fig. 1

(a) CIE transiently retarded extinction acquisition (higher fear on trial-block 2) and significantly impaired extinction retrieval, relative to air controls (air n=10, CIE n=12). (b) CIE did not affect anxiety-like behavior in the light-dark exploration test (transitions: air=19.8±10.1, CIE=13.8±2.2, p>.05), or produce tolerance to the effects of acute alcohol challenge, as measured by rotarod ataxia (=pre versus post acute alcohol) (Fig. S2: rotarod training) and the loss of righting reflex (air n=10, CIE n=12). b=baseline, Con=conditioning, RT=retrieval, RN=renewal. Data are Means ±SEM. *P<.05 CIE versus air