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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Nat Neurosci. 2012 Sep 2;15(10):1359–1361. doi: 10.1038/nn.3204

Fig. 3. CIE disrupts mPFC extinction encoding and decreases mPFC NMDAR-mediated currents.

Fig. 3

(a) In vivo freely moving recordings of IL neurons demonstrated CIE decreased neuronal activity during the first 100 milliseconds (redrawn in insets) of CS onset during late extinction (trial-block 10) and extinction retrieval (air n=7, CIE n=7, n=69-85 neurons, for a-c). (b) Coronal cartoon showing electrode placements in IL. Example extracellular waveforms and principal components separation of simultaneously recorded neurons. (c) CIE decreased CS-related IL neuronal bursting during extinction retrieval. (d) CIE decreased stimulation-evoked synaptic NMDAR-mediated currents in IL neurons, with example traces (air n=7, CIE n=8). (e) Coronal cartoon showing cannula placements in IL. (f) NMDAR antagonist AP5 infused into IL immediately after extinction training impaired extinction retrieval in alcohol-naive mice (air n=8, CIE n=7). Data are Means ±SEM. *P<.05 CIE versus air