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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Ann Biomed Eng. 2012 Aug 23;40(11):2379–2398. doi: 10.1007/s10439-012-0613-5

Figure 9.

Figure 9

Feedback control of oxidative phosphorylation in the heart. Diagram in panel A illustrates feedback-mediated control of oxidative phosphorylation in the heart. Panels B and C illustrate the simple two parameter model Pi- and ADP-driven control developed in Beard27. The two adjustable parameters in the model are the apparent Michaelis-Menten constants for the ADP and the Pi stimulation of ATP synthesis; they were measured in vitro and not adjusted but, as shown, fit the data well within the experimental variance. Data in B and C are adapted from Atkinson6, Chance40;Jeneson69; Vicini123; Balaban7 ; Wu128. Figure reprinted from Beard27 with permission.