FIGURE 3.

NMDA enhances mitochondrial uptake of Ca²⁺. Mitochondria (250 μg) were exposed to 5 μm bolus additions of Ca²⁺ in the absence (A) or presence (B) of 10 μm NMDA. In the absence of NMDA, mitochondria partially buffered four bolus additions of Ca²⁺ before uptake reached a plateau. When NMDA was included, mitochondria sequestered a total of 13 bolus additions before reaching maximum buffering capacity.