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. 2012 Aug 14;287(42):35689–35701. doi: 10.1074/jbc.M112.391839

FIGURE 1.

FIGURE 1.

Effect of the pharmacological modulation of SIRT1 activity on IL-12 p70 production and assay of NAD+ production. A, DC were incubated with 10 μg/ml LPS plus 1000 units/ml IFNγ or 1 mg/ml zymosan in the presence of the indicated additions. 24 h after the addition of the stimuli, supernatants were collected for the assay of IL-12 p70 protein. B, NAD+ was assayed in the cytoplasm and nuclear fractions of DC stimulated with zymosan for the times indicated. Results represent the mean ± S.D. of four to six independent experiments. *, p < 0.05.