FIGURE 2.

Elevated HDAC1 is toxic to neurons. A, CGNs were transfected with either GFP or HDAC1 and then switched to HK or LK medium 8 h later. Viability of transfected neurons was assessed after 24 h. Viability is normalized to cultures transfected with GFP and treated with HK. B, cortical neurons were transfected with GFP or HDAC1 for 6 h and were either left untreated (Unt) or treated with HCA. Viability of transfected neurons was assessed after 14 h and is normalized to GFP-transfected untreated cultures. Error bars indicate S.D.