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. Author manuscript; available in PMC: 2013 Mar 28.
Published in final edited form as: Cell. 2012 Sep 28;151(1):167–180. doi: 10.1016/j.cell.2012.07.034

Figure 2. CMT3 Is Enriched in Heterochromatic Regions and Highly Correlated with H3K9me2.

Figure 2

(A) Distribution of CMT3 (black) and H3K9me2 (red) along the five Arabidopsis chromosomes.

(B) CMT3 ChIP-seq signal is enriched in heterochromatic patches in the arms.

(C) Genome browser views of pericentromeric and euchromatic regions. mCG: CG methylation; mCHG: CHG methylation; mCHH: CHH methylation; TE: transposable element; PCG: protein coding gene.

(D,E) CMT3 ChIP-seq signal is not enriched in the protein coding gene regions (D), but is enriched in TEs (E).

(F,G) CMT3 (F) and H3K9me2 (G) are enriched in TEs that are upregulated in cmt3 null mutants.

(H) CMT3 and ZMET2 specifically bind to mono-, di- and tri-methylation of H3K9. Blue, red and yellow circles in right panel represent the locations of mono-, di- and tri-methylation at lysine 9-containing peptides on the array, respectively.

See also Figure S1A.