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. 2001 Jun 5;98(13):7623–7628. doi: 10.1073/pnas.121038198

Figure 6.

Figure 6

AK phosphotransfer communicates mitochondria-generated signals to KATP channels. AK molecules form a phosphorelay network connecting mitochondria with the cell membrane. Under hypoxic stress, mitochondrial FoF1-ATPase consumes cellular ATP generating ADP, which is delivered to the KATP channel through the chain of sequential AK-catalyzed phosphotransfer reactions. The inwardly rectifying potassium channel (Kir6.2) and the SUR are the pore-forming and regulatory subunits of the KATP channel complex.