Table 4. Kaplan-Meyer analysis of survival.

	Overall Survival				Progression free survival
Variables	Median OS	Median OS	Chi-	p	Median PFS	Median PFS	Chi-	p
	Altered levels	Normal levels	square		Altered levels	Normal Levels	square
CECs>20 cells/mL	8	11 (8.9–13)	0.52	0.5	9 (6–11)	10 (7.9–12)	0.64	0.4
MPs>3278 MP/µL	16	10 (6.1–13.8)	4.3	0.04	15(11.4–18)	9 (8–12)	4.02	0.04
ETG>275 nMol	7(0.11–13.8)	11 (6.6–15.3)	0.05	0.8	6 (0–14)	11	1.5	0.2

OS and PFS in patients according to pre-treatment marker levels (compared to 99^th percentile of controls).The upper reference limit levels of parameters were calculated as values higher than the 99th percentile of the control group (healthy subjects) and were set at: CECs = 20 cells/L; MPs = 3278 MP/µL; ETG = 275 mM. CEC, circulating endothelial cells; MPs, microparticles; ETG, endogenous thrombin generation.