Table 1. Optic nerve histological parameters for CNTF KO/LIF KO vs. CNTF KO/LIF HET healthy and EAE induced mice.

Parameter (Average)	Healthy LIF HET	Healthy LIF KO	P value	EAE LIF HET	EAE LIF KO	P value
Nerve area (mm2)	0.07±0.002	0.06±0.003	0.02*	0.08±0.002	0.08±0.006	0.48
Axon counts/ROI (×103 µm2)	1.92±0.09	2.14±0.01	0.16	2.00±0.07	1.75±0.08	0.02*

Comparison of key morphometric measures in the optic nerve between CNTF KO/LIF KO (LIF KO) and CNTF KO/LIF HET (LIF HET) mice in the presence and absence of EAE. Data are presented as mean ± SEM values for each parameter for each group. Region of interest (ROI) represents an area of 3480 µm².

^*P<0.05 by 2-sample t-test, assuming equal variances.