Figure 5. Treatment of Francisella-infected wax moth caterpillars with selected compounds.

G. mellonella were injected with 3×10⁴ CFU of F. novicida and treated with 9 µg of antibiotics (or 6 µg of ciprofloxacin). Surviving larvae were counted daily. A) Treatment of G. mellonella with FR900098 and ciprofloxacin. The mean time to death for untreated caterpillars was 59 hours, and for FR900098 (9 µg)- or ciprofloxacin (6 µg)-treated caterpillars it was 84 hours and 103 hours, respectively. B) Treatment of G. mellonella with fosmidomycin and compound 1. The mean time to death for caterpillars treated with fosmidomycin or compound 1 (both 9 µg) was 102 hours and 93 hours, respectively.