. 2012 Oct 15;7(10):e44581. doi: 10.1371/journal.pone.0044581

Table 1. Differences between least squares means for generations over the entire post-inoculation period, and significance of the interaction between generations and days post-inoculation.

Traits	129 vs. SJL	129 vs. F1	129 vs. F2	SJL vs. F1	SJL vs. F2
BW (%)	4.9^***	−1.3^*	−3.8^***	3.6^***	1.1 ^NS
Interaction for BW	^***	^***	^***	^***	^***
MV (ml/min)	5.1^**	−2.0^NS	−1.1 ^NS	3.1^*	4.0^**
Interaction for MV	^***	^*	NS	^***	^***
EB (%)	12^***	−4^**	−1^ns	9^***	12^***
Interaction for EB	^***	NS	NS	^***	^***
RR (min⁻¹)	38.0^***	−7.4 ^NS	−16.9^**	30.6^***	21.1^***
Interaction for RR	^***	^*	NS	^***	^***
TV (ml)	−0.014^**	−0.001 ^NS	0.006 ^NS	−0.015^**	−0.008^*
Interaction for TV	^***	^*	NS	^***	^***
LVL^d7 (log₁₀ PFU/g tissue)	3.84^***	−1.24^***	−1.60^***	2.60^***	2.23^***

The evolution (profiles) during the 7 days post-inoculation of the 129/Sv and the SJL/J parental strains were compared to the evolution (profiles) of the F1 and the F2 generations. A non significant generation-day interaction means that the profiles of the two generations involved are parallel whereas a significant one means a different pattern.

BW, relative body weight; LVL^d7, lung viral load at day 7 pi; MV, minute volume; EB, expiratory balance; RR, respiratory rate; TV, tidal volume.

^***

, p<0.001;

^**

, p<0.01 and

p<0.05. NS, non significant.