Table 3. Tagged SNPs with the most associated p-values for each MMP gene using myopia as the trait.
SNP | Gene | Minor Allele | Cases | Controls | P* | OR | 95% CI | ||
Freq. | HWE P | Freq. | HWE P | ||||||
rs470358 | MMP1 | A | 0.42 | 0.90 | 0.40 | 0.10 | 0.51 | 1.09 | 0.85–1.40 |
rs243866 | MMP2 | A | 0.23 | 0.86 | 0.26 | 0.43 | 0.28 | 0.85 | 0.64–1.14 |
rs639752 | MMP3 | A | 0.52 | 0.71 | 0.48 | 0.33 | 0.18 | 1.18 | 0.93–1.50 |
rs3740938 | MMP8 | A | 0.09 | 1.00 | 0.06 | 1.00 | 0.05 | 1.58 | 1.00–2.51 |
rs2274755 | MMP9 | A | 0.20 | 0.33 | 0.14 | 0.81 | 0.02 | 1.48 | 1.06–2.06 |
rs17099562 | MMP10 | A | 0.06 | 0.58 | 0.04 | 0.38 | 0.20 | 1.44 | 0.83–2.52 |
rs28382576 | MMP11 | A | 0.07 | 1.00 | 0.04 | 1.00 | 0.04 | 1.84 | 1.03–3.26 |
rs478927 | MMP13 | A | 0.36 | 0.50 | 0.30 | 0.77 | 0.07 | 1.27 | 0.98–1.64 |
Unadjusted P-values with a significance threshold of 0.05/50 = 0.001.