Table 4. Tagged SNPs with the most associated p-values for each MMP gene using spherical equivalent (SE), axial length (AL), anterior chamber depth (ACD) and corneal curvature (CC) as the traits.

Gene	Trait	SNP	Minor Allele		HWE	P*	OR	95% CI
			Name	Freq.
MMP1	SE	rs470747	G	0.36	0.93	0.10	1.40	0.93–2.10
	AL	rs10488	A	0.06	0.46	0.28	0.81	0.55–1.19
	ACD	rs498186	C	0.43	0.59	0.01	0.94	0.90–0.99
	CC	rs10488	A	0.06	0.46	0.02	2.40	1.17–4.92
MMP2	SE	rs11541998	C	0.11	0.13	0.17	1.52	0.83–2.77
	AL	rs11541998	C	0.11	0.13	0.25	0.83	0.61–1.13
	ACD	rs11541998	C	0.11	0.13	0.17	1.06	0.98–1.14
	CC	rs1053605	A	0.07	0.35	0.07	1.85	0.94–3.64
MMP3	SE	rs522616	G	0.21	0.19	0.37	1.23	0.78–1.96
	AL	rs522616	G	0.21	0.19	0.35	0.90	0.72–1.12
	ACD	rs3020919	A	0.24	0.29	0.15	0.96	0.91–1.02
	CC	rs3020919	A	0.24	0.29	0.51	1.15	0.75–1.76
MMP8	SE	rs3740938	A	0.08	1.00	0.02	0.42	0.20–0.85
	AL	rs11225395	A	0.46	0.93	0.01	1.28	1.05–1.54
	ACD	rs12284255	A	0.07	0.52	0.08	0.93	0.85–1.01
	CC	rs11225395	A	0.46	0.93	0.09	0.73	0.51–1.05
MMP9	SE	rs3918253	G	0.45	0.43	0.23	0.79	0.54–1.16
	AL	rs2274755	A	0.17	0.54	0.18	1.14	0.94–1.37
	ACD	rs3918253	G	0.45	0.43	0.43	0.97	0.91–1.04
	CC	rs3918253	G	0.45	0.43	0.30	0.83	0.58–1.18
MMP10	SE	rs470154	A	0.06	0.40	0.31	0.64	0.27–1.52
	AL	rs486055	A	0.15	0.87	0.06	1.29	0.99–1.69
	ACD	rs7948454	G	0.08	0.02	0.09	1.07	0.99–1.16
	CC	rs17099562	A	0.05	0.39	0.06	2.17	0.98–4.83
MMP11	SE	rs131451	G	0.12	0.29	0.02	0.50	0.28–0.90
	AL	rs738791	A	0.49	0.93	0.15	1.15	0.95–1.40
	ACD	rs738791	A	0.49	0.93	0.10	1.04	0.99–1.09
	CC	rs738792	G	0.11	0.51	0.31	0.75	0.43–1.30
MMP13	SE	rs478927	A	0.33	0.77	0.40	0.84	0.56–1.26
	AL	rs10502009	G	0.11	1.00	0.19	0.82	0.61–1.10
	ACD	rs3758854	A	0.07	0.01	0.29	1.05	0.96–1.15
	CC	rs10502009	G	0.11	1.00	0.21	1.42	0.82–2.48

^*Unadjusted P-values with a significance threshold of 0.05/50 = 0.001.