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Intrapatient variability of dose-normalized pharmacokinetic parameters calculated as the mean of CV for individual subjects across all pharmacokinetic assessments (days 7, 14, 21 and 28), with CV defined as standard deviation/mean×100
| Generic tacrolimus | Reference tacrolimus | |
|---|---|---|
| AUC0–12h, mean (SD), % | 13.4 (10.4) | 11.0 (9.8) |
| Cmax, mean (SD), % | 16.9 (15.5) | 17.9 (14.9) |
| C0, mean (SD), % | 13.2 (9.8) | 11.1 (10.3) |
