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Clotting assays were used to compare the anticoagulant activity of 3K3A-APC versus XIGRIS (wildtype recombinant APC) following their infusions in cynomolgus monkey at indicated doses (x-axis). Plasma samples were assayed as described in Methods section using aPTT assays and the aPTT prolongation data are shown in sec on y-axis; this prolongation reflects the dose-dependent anticoagulant activity of each form of APC.
