Table 1.
Mean Coagulation Parameters In Monkeys Dosed With 3K3A-APC
| Dose (mg/kg) | PT | aPTT | ||
|---|---|---|---|---|
| Mean Value1 ± SD (seconds) | Fold Increase2 | Mean Value1 ± SD (seconds) | Fold Increase2 | |
| Day 1 | ||||
| 0 | 11.7 ± 0.5 | -- | 23.9 ± 1.7 | -- |
| 0.2 | 11.2 ± 0.3 | -- | 26.1 ± 2.2 | -- |
| 1 | 11.5 ± 0.6 | -- | 36.7 ± 3.1* | 1.54 |
| 5 | 16.0 ± 2.2* | 1.37 | 109.1 ± 42.6* | 4.56 |
| Day 14 | ||||
| 0 | 11.4 ± 0.5 | -- | 23.3 ± 1.8 | -- |
| 0.2 | 11.2 ± 0.3 | -- | 26.0 ± 2.4 | -- |
| 1 | 11.3 ± 0.4 | -- | 35.2 ± 5.0* | 1.51 |
| 5 | 15.2 ± 2.3* | 1.33 | 112.0 ± 59.5* | 4.81 |
1
mean ± SD of combined male and female values measured 15 minutes following dosing
2
relative to concurrent control group value
*
p < 0.05 relative to control values