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Mean Coagulation Parameters in Monkeys 15 Minutes Following DrotAA Administration
| Dose (mg/kg) | PT | aPTT | ||
|---|---|---|---|---|
| Mean Value1 (seconds) | Fold Increase2 | Mean Value1 (seconds) | Fold Increase2 | |
| 0.02 | 12.0 ± 0.5 | -- | 28.9 ± 2.4 | -- |
| 0.1 | 12.7 ± 0.4 | -- | 36.8 ± 5.5 | 1.43 |
| 0.2 | 13.0 ± 0.3 | 1.14 | 46.2 ± 7.5 | 1.81 |
| 1 | 25.0 ± 3.0 | 2.06 | >200 * | >4.24 |
mean ± SD of combined male and female values
relative to pre-dose value
measurements were above the maximum readable by the equipment used (200 seconds)
