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Mean Coagulation Parameters in Monkeys Dosed with DrotAA
| DrotAA Dose (mg/kg) | Day Dosed | Mean aPTT ± SD (seconds) | |||
|---|---|---|---|---|---|
| Pre-Dose | 15 min | 3 hr | 24 hr | ||
| 0.02 | 1 | 25.85 ± 2.8 | 28.90 ± 2.4 | 26.27 ± 2.2 | 26.10 ± 2.8 |
| 0.1 | 3 | 25.63 ± 2.8 | 36.75 ± 5.5 | 27.30 ± 2.1 | 26.38 ± 3.0 |
| 0.2 | 5 | 25.53± 2.3 | 46.18 ± 7.5 | 28.75 ± 2.2 | 26.33 ± 2.9 |
| 1.0 | 8 | 54.20 ± 41.5 | > 200* | 42.38 ± 4.1 | 28.92 ± 3.8 |
| 1.0 | 18 | 47.13 ± 8.3 | > 200 | 66.02 ± 43.0 | 29.07 ± 4.3 |
measurements were above the maximum readable by the equipment used (200 seconds)
