Fig. 8.

Taurine deficiency induces abnormal bipolar cell plasticity. Discrete neuronal plasticity was indicated by a few extensions of Goα immunopositive bipolar cell dendrites into the ONL in the treated group (a), those extensions were absent in control animals (b). ON rod bipolar cells were stained in green with PKCα antibody and both rod and cone ON bipolar cells were stained in red with Goα antibody (c, d): co-immunolabelled dendrites extending into the ONL were observed in GES-treated mice (c) and not in controls (d) indicating a synaptic plasticity in rod bipolar cells. Scale bars represent 25 μm (ONL outer nuclear layer, OPL outer plexiform layer, INL inner nuclear layer, IPL inner plexiform layer, RGCL retinal ganglion cell layer)