Table 4.
The effect of number of plasma samples and subject population on the accuracy (ratio) and precision (SD) of PBIF and IDIF to estimate area-under-the-curve (AUC) and distribution volume (VT) compared to arterial input function.
| Method | Population | Number of plasma samples |
AUC (ratio ± SD) |
VT (ratio ± SD) |
|---|---|---|---|---|
| PBIF | healthy | 2 | 1.02 ± 0.07 | 1.02 ± 0.07 |
| PBIF | healthy | 3 | 1.02 ± 0.07 | 1.02 ± 0.05 |
| PBIF | MDD | 2 | 1.02 ± 0.08 | 1.04 ± 0.06 |
| PBIF | MDD | 3 | 1.04 ± 0.07 | 1.03 ± 0.04 |
| PBIF | mixed (flat curves) | 2 | 1.08 ± 0.06 | 1.08 ± 0.05 |
| PBIF | mixed (flat curves) | 3 | 1.10 ± 0.05 | 1.06 ± 0.04 |
| PBIF | mixed (steep curves) | 2 | 0.97 ± 0.06 | 0.99 ± 0.06 |
| PBIF | mixed (steep curves) | 3 | 0.96 ± 0.05 | 0.99 ± 0.04 |
| IDIF | healthy | 4 | 1.02 ± 0.06 | 0.99 ± 0.05 |
| IDIF | MDD | 4 | 1.00 ± 0.04 | 1.00 ± 0.04 |