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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Hum Genet. 2012 Jul 3;131(11):1751–1759. doi: 10.1007/s00439-012-1195-x

Table 5.

Trisomy 21 IPA significant diseases and disorders

Category P value range* No. of
genes
Neurological disease 2.76E–12 to 4.61E–02 201
Dermatological diseases and conditions 7.05E–06 to 3.06E–02 114
Infectious disease 6.52E–05 to 4.20E–02 177
Reproductive system disease 1.97E–04 to 2.51E–04   96
Connective tissue disorders 7.38E–03 to 4.61E–02     6
Respiratory disease 4.61E–02     6
Cardiovascular disease 4.20E–02     4
*

Benjamini–Hochberg corrected right-tailed Fisher exact P value ranges for individual functional annotations within each category