Table 1.
Patient characteristics at biopsy from 37 Pima Indians with type 2 diabetes mellitus.
| Donors (n=10) |
Normo- (n=11) |
Micro- (n=16) |
Macro- (n=10) |
P value | |||
|---|---|---|---|---|---|---|---|
| Fraction female | 5/10 | 10/11 | 11/16 | 5/10 |
a0.064 d0.350 |
b0.425 e0.064 |
c1.000 f0.425 |
| Age (years) | 47±11.7 | 45.7±11.0 | 48.1±9.0 | 48.3±7.3 |
a0.959 d0.512 |
b0.806 e0.605 |
c1.000 f0.698 |
| BMI (kg/m2) | 25.2±3.2 | 35.9±7.7 | 35.5±8.5 | 34.5±8.0 |
a6.8·10−5 d0.716 |
b2.5·10−4 e0.512 |
c0.002 f0.897 |
| Duration (years) | N/A | 12.6±3.0 | 16.4±7.2 | 19.8±5.4 |
aN/A d0.178 |
bN/A e0.002 |
cN/A f0.100 |
| HbA1c (%) | N/A | 7.7±1.4 | 8.4±2.3 | 9.8±1.6 |
aN/A d0.181 |
bN/A e0.008 |
cN/A f0.205 |
| MAP (mmHg) | 92±11 | 88±8 | 94±9 | 98±15 |
a0.512 e0.131 |
b0.542 e0.173 |
c0.363 f0.525 |
| ACR (mg/g) | 5 (3–91) |
19 (7–26) |
61 (36–212) |
978 (358–3762) |
§ | § | § |
| GFR (ml/min) | 110±24 | 127±48 | 172±56 | 111±49 |
a0.191 d0.030 |
b0.002 e0.314 |
c0.670 f0.004 |
| Anti- hypertensive treatment (%)* |
0 | 27.3 | 62.5 | 60.0 |
a0.214 d0.120 |
b0.003 e0.198 |
c0.011 f1.000 |
P values are shown for
a
donors vs. normo-,
b
donors vs. micro-,
c
donors vs. macro-,
d
normo vs. micro-,
e
normo- vs. macro-, and
f
micro- vs. macroalbuminuric groups.
P values less than 0.05 are shown in bold.
Data are means ± SD, median (range), or percent. MAP, mean arterial pressure; ACR, albumin-to-creatinine ratio; GFR, glomerular filtration rate.
*
Anti-hypertensive treatment included angiotensin converting enzyme inhibitors and/or angiotensin receptor blockers in any patients receiving therapy, including the drug provided as part of the trial; N/A, not applicable.
§
ACR values by group are different by definition.