Table 3.
Spearman's correlations (P-values) between physiologic and morphometric variables in 37 Pima Indians with type 2 diabetes mellitus.
| GFR | ACR | % GS | VG | FIA | AA | SV | SA | GBM | # E+M | # Podo | FSF | FPW | % Det | % Fen | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GFR | 1.0 | −0.12 (0.471) |
−0.25 (0.143) |
0.41 (0.012) |
−0.24 (0.151) |
−0.35 (0.036) |
0.24 (0.151) |
0.49 (0.002) |
−0.24 (0.154) |
0.01 (0.948) |
0.21 (0.207) |
−0.13 (0.457) |
0.15 (0.366) |
−0.30 (0.071) |
0.44 (0.006) |
| ACR | 1.0 | 0.31 (0.059) |
0.23 (0.174) |
0.48 (0.003) |
0.55 (<0.001) |
−0.47 (0.003) |
−0.27 (0.106) |
0.50 (0.002) |
0.41 (0.011) |
−0.14 (0.424) |
−0.50 (0.002) |
0.55 (<0.001) |
0.36 (0.028) |
−0.45 (0.006) |
|
| % GS | 1.0 | −0.09 (0.586) |
0.36 (0.028) |
0.25 (0.133) |
−0.35 (0.031) |
−0.28 (0.087) |
0.15 (0.360) |
0.17 (0.296) |
0.12 (0.476) |
−0.14 (0.406) |
0.14 (0.397) |
0.06 (0.730) |
−0.33 (0.044) |
||
| VG | 1.0 | −0.22 (0.192) |
0.04 (0.801) |
−0.26 (0.118) |
0.44 (0.006) |
0.15 (0.366) |
0.57 (<0.001) |
0.41 (0.012) |
−0.29 (0.082) |
0.35 (0.036) |
−0.05 (0.743) |
−0.01 (0.974) |
|||
| FIA | 1.0 |
0.38 (0.021) |
−0.26 (0.115) |
−0.37 (0.073) |
0.37 (0.026) |
0.16 (0.342) |
−0.22 (0.182) |
−0.23 (0.161) |
0.30 (0.074) |
0.25 (0.141) |
−0.33 (0.049) |
||||
| AA | 1.0 |
−0.73 (<0.001) |
−0.64 (<0.001) |
0.71 (<0.001) |
0.37 (0.024) |
−0.19 (0.250) |
−0.50 (0.002) |
0.59 (<0.001) |
0.19 (0.248) |
−0.54 (<0.001) |
|||||
| SV | 1.0 |
0.69 (<0.001) |
−0.50 (0.002) |
−0.43 (0.008) |
0.10 (0.537) |
0.52 (0.001) |
−0.51 (0.001) |
−0.40 (0.014) |
0.65 (<0.001) |
||||||
| SA | 1.0 |
−0.45 (0.005) |
0.05 (0.773) |
0.48 (0.002) |
0.22 (0.184) |
−0.168 (0.321) |
−0.38 (0.021) |
0.55 (0.056) |
|||||||
| GBM | 1.0 | 0.18 (0.285) |
−0.39 (0.017) |
−0.32 (0.051) |
0.38 (0.020) |
0.07 (0.672) |
−0.38 (0.019) |
||||||||
| # E+M | 1.0 |
0.49 (0.002) |
−0.35 (0.032) |
0.43 (0.009) |
−0.00 (0.999) |
−0.42 (0.010) |
|||||||||
| # Podo | 1.0 | 0.16 (0.361) |
−0.05 (0.756) |
−0.42 (0.011) |
0.06 (0.693) |
||||||||||
| FSF | 1.0 |
−0.93 (<0.001) |
−0.36 (0.027) |
0.27 (0.102) |
|||||||||||
| FPW | 1.0 | 0.28 (0.088) |
−0.28 (0.091) |
||||||||||||
| % Det | 1.0 | −0.25 (0.131) |
|||||||||||||
| % Fen | 1.0 |
P values less than 0.05 are shown in bold.
GFR, glomerular filtration rate (ml/min); ACR, albumin to creatinine ratio (mg/g); % GS, % global sclerosis; VG, glomerular volume (µm3); FIA, fractional interstitial area (%); AA, fractional mesangial area (%); SV, filtration surface area density (µm2/µm3); SA, total surface area (µm2); GBM, glomerular basement membrane width (nm); # E+M, number of endothelial + mesangial cells per glomerulus; # Podo, number of podocytes per glomerulus; FSF, filtration slit frequency (number/mm); FPW, foot process width (nm); % Det, % podocyte detachment along GBM; % Fen, % fenestrated endothelial cells.