Table 2.

Compound ID, structures & activity

Compound	Chemical structure	ΔTm (°C)	IC50 (nM)	EC50 (nM)	Resolution of structure
Aminoquinolones
1289		12	13	30	3.1 Å
1312		12	8	4	3.1 Å
1320		8.6*	65	100	2.7 Å
Benzimidazoles
1325		10.5	43	77	2.95 Å
1331		9.8	46	22	2.75 Å
Low molecular weight compound
89		1.8**	ND	ND	2.6 Å

^*Concentration used for ΔT_m determination is 50 µM in the presence of 10 mM Met, ATP and Mg²⁺ instead of 100 µM used for the other inhibitors

^**Concentration used for ΔT_m determination is 800 µM against TbMetRS in the absence of Met, ATP and Mg²⁺