Fig. 4.

Deformities in the roots and periodontium of Col1a1-cre:Catnb^+/lox(ex3) mice. (A, B) In contrast to WT mice, RD is thin and hypomineralized in MT mice. In addition, PS is narrower due to excessive formation of alveolar bone in MT mice. (C, D) In the RD of MT mice, Dspp is decreased in the dentin. (E-J) In WT mice, Bsp, Dmp1 and Fgf23 are specifically localized in the matrix of acellular cementum (arrows) and alveolar bone, which is decreased in the MT mice. (K, L) Osteopontin is localized in the cementum and periodontal ligaments of WT mice. It is also decreased in the cementum and periodontal ligaments of MT mice. WT, wild type; RD, root dentin; H&E, hematoxylin and eosin; MT, mutant; PS, periodontal space; Dspp, dentin sialophosphoprotein; Bsp, bone sialoprotein; Dmp1, dentin matrix protein-1; Fgf23, fibroblast growth factor-23; Opn, osteopontin. Scale bar=50 µm (A-L).