Skip to main content
. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Free Radic Biol Med. 2012 Aug 25;53(9):1738–1747. doi: 10.1016/j.freeradbiomed.2012.08.576

Fig. 1. Effects of deferoxamine (DFO) on chronic hypoxia-induced pulmonary hypertension in intact rats.

Fig. 1

Rats were intraperitoneally injected daily with saline (vehicle control) or 20 mg/kg body weight of DFO during 2-week exposure to normoxia or hypoxia (10% O2). (A) Right ventricular systolic pressure (RVSP) was measured using a Millar catheter (n = 3). (B) RV/(LV+S) values (n = 3 – 6). (C) H & E staining showing small pulmonary arteries (PA) and arterioles with the diameter ranging 53–113 μm. Scale bars, 50 μm. The bar graph represents means ± SEM of % wall thickness (n = 3). *, P<0.05 vs. normoxia; a, P<0.05 vs. hypoxia.