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. Author manuscript; available in PMC: 2013 Nov 10.
Published in final edited form as: J Mol Biol. 2012 Aug 9;423(5):664–676. doi: 10.1016/j.jmb.2012.07.027

Figure 7. Proposed Model for Direct Interaction of Rho and RNAP.

Figure 7

Epshtein et al.49 proposed that Rho directly associates with RNAP throughout transcription (dashed lines). In this model, such an association would generate a loop of RNA, composed of sequences downstream of the rut site and upstream of RNAP, that shortens continuously during translocation. Furthermore, in the tethered-tracking mechanism, a second loop is expected to form, composed of sequences between the primary and secondary Rho binding sites, that lengthens continuously at the identical rate. Our results disfavor any strong, direct interaction between Rho and RNAP.