Table 4.

Information of proteins ranked in top 100 by ION, PeC, NC and DC

method	Number of essential proteins	Number of proteins belonging to complex	Average number of orthologs	average interaction rate with known complex
ION	78	72	93	0.39
PeC	74	57	78	0.37
NC	55	59	65	0.32
DC	46	53	62	0.33

This table shows the statistic information of proteins ranked in top 100 by ION, PeC, NC and DC. Column “Number of essential proteins” presents the number of essential proteins in the proteins ranked in top 100 by corresponding methods. Column “Number of proteins belonging to complex” presents how many proteins ranked in top 100 by corresponding methods belong to a least one known complex. Column “Average number of orthologs” presents the average number of orthologs that the proteins ranked in top 100 by corresponding methods have in reference organisms. Column “average interaction rate with known complex” presents the average interaction rate between the sub-complexes including these proteins and known complexes.