Table 9.
Changes (percent composition) in rat brain phosphatidylethanolamine molecular species following intraventricular infusion with propionic acid (PPA) and phosphate buffered saline (PBS)
| Molecular weight | Molecular species | Plasmalogen or diacyl species | PBS | PPA |
|---|---|---|---|---|
| 700 |
P34:1 |
p16:0/18:1 |
5.85 ± 0.15 |
5.10 ± 0.14* |
| 714 |
D34:2 |
16:0/18:2 |
3.37 ± 0.17 |
3.49 ± 0.15 |
| 730 |
P36:0 |
p18:0/18:0 |
3.42 ± 0.13 |
4.03 ± 0.38 |
| 744 |
D36:1 |
18:0/18:1 |
3.50 ± 0.46 |
3.32 ± 0.37 |
| 728 |
P36:1 |
p18:0/18:1 |
6.00 ± 0.09 |
6.82 ± 0.12* |
| 742 |
D36:2 |
18:0/18:2 |
3.68 ± 0.14 |
3.59 ± 0.35 |
| 726 |
P36:2 |
p18:0/18:2 |
4.79 ± 0.30 |
7.16 ± 0.62* |
| 724 |
P36:3 |
p18:1/18:2 |
3.38 ± 0.42 |
2.98 ± 0.27 |
| 722 |
P36:4 |
p16:0/20:4 |
4.32 ± 0.12 |
4.43 ± 0.14 |
| 766 |
D38:4 |
18:0/20:4 |
6.99 ± 0.71 |
7.33 ± 0.62 |
| 750 |
P38:4 |
p18:0/20:4 |
6.07 ± 0.13 |
7.70 ± 0.02* |
| 762 |
D38:6 |
16:0/22:6 |
4.18 ± 0.16 |
3.45 ± 0.15* |
| 746 |
P38:6 |
p16:0/22:6 |
5.14 ± 0.45 |
5.11 ± 0.80 |
| 796 |
D40:3 |
18:0/22:3 |
3.59 ± 0.26 |
3.52 ± 0.43 |
| 794 |
D40:4 |
20:0/20:4 |
3.51 ± 0.08 |
3.85 ± 0.42 |
| 778 |
P40:4 |
p18:0/22:4 |
3.46 ± 0.26 |
5.00 ± 0.10* |
| 792 |
D40:5 |
18:0/22:5 |
4.30 ± 0.31 |
3.93 ± 0.41 |
| 776 |
P40:5 |
p18:0/22:5 |
3.91 ± 0.69 |
3.79 ± 0.60 |
| 790 |
D40:6 |
18:0/22:6 |
11.07 ± 1.06 |
8.59 ± 0.36* |
| 774 |
P40:6 |
p18:0/22:6 |
9.47 ± 0.21 |
6.82 ± 0.86* |
|
Total% |
|
|
100 |
100 |
|
∑ Saturates |
|
|
3.42 ± 0.12 |
4.02 ± 0.38 |
|
∑ Monounsat |
|
|
15.32 ± 0.65 |
15.23 ± 0.92 |
|
∑ Polyunsat |
|
|
81.23 ± 0.69 |
80.73 ± 0.55 |
| ∑ Plas | 55.82 ± 1.63 | 58.93 ± 1.40 |
Values (nanomole percent by weight composition) represent means ± standard errors. Means in the same row accompanied by asterisks are significantly different between treatments at LSD = 0.05, n = 12 per treatment group. D represents diacyl species and P represents plasmalogens species, p denotes a sn-1 vinyl ether (plasmalogen) linkage. Monounsat, monounsaturated fatty acids; PBS, phosphate buffered saline solution; plas, plasmalogens; polyunsat, polyunsaturated fatty acids; PPA, propionic acid. Phosphatidylethanolamine molecular species were identified using a precursor ion scan of m/z 196 in ESI negative mode. The lipid components in the table are arranged based on the molecular species composition.