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. 2012 Jun 21;11:209. doi: 10.1186/1475-2875-11-209

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Copyright ©2012 Schuldt et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ad5-CSP/Ad5-CSP vaccination resulted in higher percentage of tetramer positive CD8⁺T cells than Ad4-CSP/Ad5-CSP in the spleen. Splenocytes and PBMCs were collected two weeks after final vaccination. All vaccination regimens resulted in significantly higher percentage of CD3⁺ CD8⁺ NYDNAGTNL tetramer positive T cells in the spleen (A) and circulating blood (B) as measured by flow cytometry, cells were stained with CD8-Alexa flour700, CD3-APC-Cy7, and CSP (NYD)-Tetramer-PE. Ad5-CSP/Ad5-CSP stimulated a higher percentage of CD3⁺ CD8⁺ tet⁺ than Ad4-CSP/Ad5-CSP treated animals in the spleen (A) and higher percentage of CD3⁺ CD8⁺ tet⁺ than Ad4-CSP/Ad4-CSP in the circulating blood (B). Bars represent ± standard error. Statistical analysis was completed using One Way ANOVA with Student-Newman-Keuls post-hoc test, *, **, *** denotes significance over naïve, P < 0.05, P < 0.01, P < 0.001.