Table 2.

Modifications in previous families

Group	Existing Families
	Before classification	After classification
HTH
	Cro & repressor	Renamed to Cro and cro like
	Diptheria tox repressor	Renamed to iron dependent repressor
Zinc Co-ordinating
	Harmone Nuclear Receptor	Renamed to Nuclear receptors
	GAL4 type	Renamed to Gal 4 and Gal 4 like
Zipper type
	Leucine Zipper	Has subfamilies bzip1 and bzip2
Other-α Helix
	Cre Recombinase	Renamed to Site specific recombinases
Other
	ReI homology	Renamed to Ig fold like Transcription factor
Enzyme
	DNA polymerase β	Merged and splitted into DNA Polymerase A, B, C, X and Y
	DNA Polymerase I
	DNA Polymerase T7
	Uracil DNA glycosylase	Has 3 subfamilies Human UDG, Xenopus UDG and T. thermophilus UDG

The previously recognised 54 families were split, renamed or merged while classification in order to populate them with the new members. The families listed below have been marked appropriately if they were renamed or split or merged. 17% of the families underwent these treatment. (Rest of the previously recognised families which are not listed did not get change and were populated with new members).