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. Author manuscript; available in PMC: 2013 Oct 25.
Published in final edited form as: Neuroscience. 2012 Aug 13;223:285–295. doi: 10.1016/j.neuroscience.2012.08.009

Figure 2.

Figure 2

Decrease in progenitor cell proliferation in Dicer depleted cortical tissue. (A) Representative photomicrograph showing IHC for PH3 in cerebral cortices at both E15.5 and E16.5. Scale bars, 100 μm. (B) Quantification of IHC staining of E15.5 and E16.5 PH3 positive cells within the medial-lateral plane in matched sections shows decreased proliferating cells within Dicer depleted cortical tissue. Ctrl, control (fd/fd;+/+); Dd, conditional Dicer depleted (fd/fd;nCre/+). Y-axis denotes number of PH3 positive cells per 1000 total cells as defined by Hoechst staining in a 20x field. Error bars represent mean ± SEM. ***p<0.0001 using a two-tailed unpaired t-test.