Table 1.
Significant BOLD response differences between the study groups
Contrasts with significant differences in BOLD responses | Talairach Coordinates | Brain Region | Brodmann Area | ke | t | Corrected significance (p) | Significance differences in percent BOLD signal changes between groups | ||
---|---|---|---|---|---|---|---|---|---|
Retrieval SZ > HC | 33 | 6 | 57 | Right middle frontal gyrus | BA 8 and 9 | 730 | 5.01 | 5.0 × 10−6 | 0.00006 |
−27 | −15 | 63 | Left precentral gyrus | BA 6 | 620 | 4.89 | 7.3 × 10−6 | 0.0002 | |
−18 | −21 | 0 | Left thalamus (pulvinar & posterior lateral) | 158 | 4.65 | 1.6 × 10−5 | 0.0005 | ||
22 | −19 | 14 | Right ventral posterior lateral thalamus | 154 | 4.16 | 5.1 × 10−6 | 0.0005 | ||
−27 | −24 | 21 | Left insula | BA 13 | 217 | 4.50 | 1.6 × 10−5 | 0.0004 | |
36 | 9 | 12 | Right insula | BA 13 | 170 | 3.85 | 5.8 × 10−5 | 0.0005 | |
Retrieval SZ > FDR | −51 | −9 | 21 | Right pre and post central gyri | BA 43 & 6 | 912 | 5.28 | 4.8 × 10−6 | 0.00002 |
18 | 9 | 69 | Right superior frontal gyrus | BA 8, 9 & 6 | 784 | 5.27 | 5.1 × 10−6 | 0.0009 | |
54 | −39 | 24 | Right insula | BA 13 | 106 | 3.58 | 1.7 × 10−4 | 0.0006 | |
24 | −24 | 3 | Right thalamus | 104 | 3.69 | 4.3 × 10−4 | 0.02 | ||
Retrieval FDR > HC | −45 | −48 | 21 | Left Inferior Parietal Lobule | BA 40 | 90 | 3.42 × 10−4 | 0.019 | |
0 | −87 | 27 | Left Cuneus | BA 19 | 256 | 4.88 | 6.46 × 10−6 | 0.012 |
Note: SZ=Schizophrenia; HC=Healthy Control Subjects; FDR=First-degree relatives; BA=Brodmann area