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. Author manuscript; available in PMC: 2012 Oct 16.
Published in final edited form as: Ann N Y Acad Sci. 2009 Sep;1174:68–73. doi: 10.1111/j.1749-6632.2009.04941.x

Figure 1. Spontaneous tumors that develop in p53−/− mice overexpress cyclin B1 in the cytoplasm.

Figure 1

Thymus (B) and spleen (D) from a wild type mouse do not overexpress cyclin B1. In a p53−/− mouse, (A) the primary tumor (thymoma) and (C) tumor cells metastasizing to the spleen exhibit cyclin B1 overexpression. Non-tumor cells in both the thymus and the spleen of the p53−/− mouse are negative for cyclin B1 overexpression.