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. Author manuscript; available in PMC: 2012 Oct 16.
Published in final edited form as: Ann N Y Acad Sci. 2009 Sep;1174:68–73. doi: 10.1111/j.1749-6632.2009.04941.x

Figure 2. Cyclin B1 DNA prime/protein boost vaccine elicits an anti-cyclin B1 immune response and delays spontaneous tumor growth in p53−/− mice.

Figure 2

p53−/− mice at 4–6 weeks of age were vaccinated with pcDNA3.1 with mouse cyclin B1 (mCB1) cDNA and boosted with the LT/IS patch + mCB1 protein twice at 3 week intervals. Control mice received empty DNA vector and the LT/IS patch or no treatment. (A) DNA prime/protein boost vaccination elicits anti-cyclin B1 IgG. Bars indicate mean OD. (B) Cyclin B1 vaccination retarded spontaneous tumor growth. The dotted line indicates the time point at which 50% of the mice in each group died.