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Phenotypic analysis of adrenergic-deficient (Dbh−/−) mouse embryonic development. In vivo ultrasound image of a wild-type embryonic day 10.5 (E10.5) mouse embryo in systole (A) and diastole (B). Crown-rump lengths were estimated as indicated. C: heart rates (means ± SE) for the corresponding embryonic ages, as assessed by high-resolution ultrasound imaging. D: attrition rates by genotype between E9.5 and E11.5.
