Table 3.
Genome-wide association mapping for exercise time in male mice from classical and wild-derived inbred strains using a 4 million SNP panel
| Chr. | QTL Location, Mb | Peak SNP | P Value | Known Genes, n |
|---|---|---|---|---|
| Classical and wild-derived inbred strains | ||||
| 1 | 180.76 | rs39502136 | 1.01 × 10−7 | 2 (Kif26b) |
| 11 | 21.65–22.58 | rs4135796 | 2.75 × 10−8 | 9 (AV249152) |
| rs26852365 | 2.75 × 10−8 | (Ehbp1) | ||
| Classical inbred strains only | ||||
| 1 | 178.54–180.76 | rs39502136 | 2.43 × 10−8 | 24 (Kif26b) |
| 2 | 168.40–168.43 | rs27288988 | 1.13 × 10−6 | 1 (Nfatc2) |
| 11 | 21.65–22.56 | rs4135796 | 3.29 × 10−7 | 9 (AV249152) |
| rs3708339 | 3.29 × 10−7 | (AV249152) | ||
| rs26852365 | 3.29 × 10−7 | (Ehbp1) | ||
| 11 | 70.92–71.09 | rs282333136 | 3.31 × 10−6* | 3 (Nlrplc) |
*
P value corresponding to a genome-wide false discovery rate of ≤10% (q value of ≤0.10). All other results are significant based on genome-wide thresholds corresponding to P values of 1.01 × 10−7 for 34-strain and 2.54 × 10−6 for 30-strain cohorts. Gene symbol in parentheses indicates the gene containing the peak SNP. Kif26b, kinesin family member 26B; AV249152, WD repeat containing planar cell polarity effector; Ehbp1, EH domain binding protein 1; Nfatc2, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; Nlrplc, NLR family, pyrin domain containing 1C.