Table 4.
Genome-wide association mapping for body mass in male mice from classical and wild-derived inbred strains
| Chr. | QTL Location, Mba | Peak SNP | Known Genes, n | Previous QTL |
|---|---|---|---|---|
| Classical and wild-derived inbred strains | ||||
| 1 | 54.08 | rs6406541 | 1 (Hecw2) | |
| 3 | 109.58 | rs29791710 | 2 | Bwq8 |
| Classical inbred strains only | ||||
| 2 | 59.19 | rs6238344 | 5 | Pbwg1, Bwtq8 |
| 4 | 41.42–41.69 | rs6222957 | 13 | Wtlr3, Bwtq9, Wta1 |
| 9 | 93.76–98.14 | rs6360988 | 28 (Acpl2) | Bwq6 |
| 9 | 99.78 | rs6387071 | 3 | Bwq6 |
| 15 | 29.20 | rs13482501 | 0 | Dob3 |
| 17 | 48.77 | rs29537880 | 3 | Obwq4, W10q12, W6q11, Bodwt2, Wta4 |
All associations with P value <10−5 are reported. Gene symbol in parentheses indicates the gene containing the peak SNP. aFor single SNP associations, the QTL interval for candidate gene identification was estimated to be 400 kb centered around the peak SNP. Hecw2, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; Acpl2, acid phosphatase-like 2; Bwq8, body weight QTL 8 (39); Pbwg1, postnatal body weight growth 1 (35); Bwtq8, body weight QTL 8 (36); Wtlr3, weight loss response 3 (32); Bwtq9, body weight QTL 9 (36); Wta1, weight adult 1 (7); Bwq6, body weight, QTL 6 (30); Dob3, dietary obesity 3 (43); Obwq4, obesity and body weight QTL 4 (36); W10q12, weight 10 wk QTL 12 (33); W6q11, weight 6 wk QTL 11 (33); Bodwt2, body weight 2 (38); Wta4, weight adult 4 (7).