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. 2012 Aug 28;44(20):957–969. doi: 10.1152/physiolgenomics.00184.2011

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Fig. 3. — MAO-A inhibition reduces mitochondrial respiratory control index (RCI) in hearts from adult, aged, and aged OVX female F344 rats. RCI was determined in the presence of 2.5 mM α-ketoglutarate + 1 mM malate (Complex I; A), or 1 μM rotenone + 2.5 mM succinate (Complex II; B) following treatment with 5 μM clorgyline during state 2 respiration. All values are displayed as mean RCI (state 3/state 2) ± SE from n = 2–4 independent experiments. *Main effect of clorgyline P < 0.005; n = 3–4/group.